Here we administered Lactobacillus plantarum PS128 (PS128) to a germ-free (GF) mouse model to investigate the impact of the gut-brain axis on emotional behaviors. [10] In depressed mice that have been subjected to early-life stress, this same psychobiotic decreases cortisol, normalizes the stress response system (the HPA axis), and decreases depression. Lactobacillus plantarum strain PS128, for example, is known to increase dopamine and serotonin and decrease depression-like behaviors in mice. Lactobacillus plantarum is a widespread member of the genus Lactobacillus, commonly found in many fermented food products as well as anaerobic plant matter.It is also present in saliva (from which it was first isolated).
Liu et al. Lactobacillus plantarum PS128 in one of bacteria extracted from traditional fermented food, Fu-Tsai. It can alleviate depressive-like behavior reduce inflammation level in maternal separation mice. To rule out the possible toxicity of PS128, we administered both live and heat-killed PS128 to GF mice for 16 days and examined the physical and histological changes of GF mice.
As indicated by the Neighbor-Joining phylogenetic analysis, the 16S rDNA sequence of strain PS128 is closest to that of strain WCFS1 (which was the first L. plantarum strain to have its complete genome published) and that of L. plantarum B21 (Fig. This four-week, randomized, double-blind, placebo-controlled study investigated the effects of Lactobacillus plantarum PS128 (PS128) on boys with autism spectrum disorder (ASD) aged … Lactobacillus spp. These strains were tested for potency, effectiveness, and the ability to affect mental wellness. Gut Pathog 21 22 DOI 10.1186/s13099-015-0068-y SHORT REPORT Genome architecture of Lactobacillus plantarum PS128, a probiotic strain with potential immunomodulatory activity Wei‑Hsien Liu1†, Chih‑Hsien Yang 2,3†, Ching‑Ting Lin4, Shiao‑Wen Li2, Wei‑Shen Cheng 2, Yi‑Ping Jiang 1, Chien‑Chen Wu1, Chuan‑Hsiung Chang2,3* and Ying‑Chieh Tsai 1,5* To continue our series on probiotics, I’m going to introduce you to another important strain – Lactobacillus plantarum.As with other probiotics, this strain supports the digestive system and encourages healthy immune function.This strain, when combined with other beneficial strains of bacteria, may support overall health and wellbeing. 2). First, we demonstrated that chronic administration of live PS128 showed no adverse effects on physical health. 16S rDNA phylogenetic analysis of PS128 and other sequenced Lactobacilli. As indicated by the Neighbor-Joining phylogenetic analysis, the 16S rDNA sequence of strain PS128 is closest to that of strain WCFS1 (which was the first L. plantarum strain to have its complete genome published) and that of L. plantarum B21 (Fig. L. plantarum is Gram positive, bacilli shaped bacterium.L. The strain Lactobacillus plantarum PS128 was isolated after a rigorous screening process of nearly one thousand strains of bacteria. Lactobacillus plantarum suggested Streptobacteri um plantarum by Orla-Jensen in 1919, is a facultative heterofermentative lactic acid bacterium, which is too great extent dispersed in nature [33]. has long been used as an additive in health foods, including fermented milk drinks .However, there is minimal safety data regarding long-term ingestion of lactic acid bacteria in GF mice.